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Laboratory Instruments Instruments purchased through European Regional Development Fund. CZ.02.1.01/0.0/0.0/15_003/0000495
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Virology doc.RNDr. Daniel RŮŽEK, Ph.D.
Chemistry And Toxicology RNDr. Miroslav MACHALA, CSc.
Biotechnology and Immunology UPOL Prof. MUDr. Mgr. Milan RAŠKA, Ph.D.
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International Symposium - Innovative Health Care Technologies in Chemistry and Virology International Symposium​“Innovative Health Care Technologies in Chemistry and Virology”took place on 27.5.2019 at Veterinary Research Institute Brno, Czech Republic
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Laboratory Instruments These instruments were financed by Regional Development Fund. CZ.02.1.01/0.0/0.0/15_003/0000495
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Chemistry And Toxicology

RNDr. Miroslav MACHALA, CSc.
  • Analytical & medicinal chemistry
  • Lipidomics
  • Advanced toxicological analyses

The Department of Chemistry and Toxicology led by RNDr. Miroslav Machala, CSc. focuses on chemical analysis of complex mixtures of aromatic compounds in the environment and food chain using current analytical methods. At the same time, they study toxicity mechanisms of organic xenobiotics (polycyclic aromatic hydrocarbons, persistent organic pollutants such as dioxins and polychlorinated biphenyls and polar aromatic compounds), especially the processes of chemical carcinogenesis and endocrine disruption, at both molecular biological and biochemical levels (changes of gene expression, DNA damage and post-genotoxic response, intracellular signal transduction, effects in the plasma membrane, and comprehensive lipidomic analysis), and at the level of cell populations (modulation of the cell cycle, proliferation, apoptosis and differentiation; intercellular communication, cell adhesion and transformation). Data produced by this Department are used by the European Agency for Food Safety and by the WHO for risk assessment of environmental and food contaminants.