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Research Research
Laboratory Instruments Instruments purchased through European Regional Development Fund. CZ.02.1.01/0.0/0.0/15_003/0000495
Publications Articles published under the Project FIT
Patents And Inventions Patents filed under Project FIT
Teams Teams
Pharmacology And Immunotherapy doc. RNDr. Jaroslav TURÁNEK, CSc.
Virology doc.RNDr. Daniel RŮŽEK, Ph.D.
Chemistry And Toxicology RNDr. Miroslav MACHALA, CSc.
Biotechnology and Immunology UPOL Prof. MUDr. Mgr. Milan RAŠKA, Ph.D.
News News
11th International Conference "Drug Delivery Systems" in Telč 11th international conference on Drug Delivery Systems: "Nanotechnology for Healthcare" was held at Jesuit college in Telč on 5th - 7th June 2018.
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Laboratories and VRI campus Place for our scientists
Laboratory Instruments These instruments were financed by Regional Development Fund. CZ.02.1.01/0.0/0.0/15_003/0000495
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Chemistry And Toxicology

RNDr. Miroslav MACHALA, CSc.
  • Analytical & medicinal chemistry
  • Lipidomics
  • Advanced toxicological analyses



The Department of Chemistry and Toxicology led by RNDr. Miroslav Machala, CSc. focuses on chemical analysis of complex mixtures of aromatic compounds in the environment and food chain using current analytical methods. At the same time, they study toxicity mechanisms of organic xenobiotics (polycyclic aromatic hydrocarbons, persistent organic pollutants such as dioxins and polychlorinated biphenyls and polar aromatic compounds), especially the processes of chemical carcinogenesis and endocrine disruption, at both molecular biological and biochemical levels (changes of gene expression, DNA damage and post-genotoxic response, intracellular signal transduction, effects in the plasma membrane, and comprehensive lipidomic analysis), and at the level of cell populations (modulation of the cell cycle, proliferation, apoptosis and differentiation; intercellular communication, cell adhesion and transformation). Data produced by this Department are used by the European Agency for Food Safety and by the WHO for risk assessment of environmental and food contaminants.