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Laboratory Instruments Instruments purchased through European Regional Development Fund. CZ.02.1.01/0.0/0.0/15_003/0000495
Publications Articles published under the Project FIT
Patents And Inventions Patents filed under Project FIT
Teams Teams
Pharmacology And Immunotherapy doc. RNDr. Jaroslav TURÁNEK, CSc.
Virology doc.RNDr. Daniel RŮŽEK, Ph.D.
Chemistry And Toxicology RNDr. Miroslav MACHALA, CSc.
Biotechnology and Immunology UPOL Prof. MUDr. Mgr. Milan RAŠKA, Ph.D.
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11th International Conference "Drug Delivery Systems" in Telč 11th international conference on Drug Delivery Systems: "Nanotechnology for Healthcare" was held at Jesuit college in Telč on 5th - 7th June 2018.
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Publications

2020

Three-dimensional reconstruction of the feeding apparaturs of the tick Ixodes ricinus (Acari: Ixodidae): a new insight into the mechanism of blood-feeding. 2020. Vancová M, Bílý T, Šimo L, Touš J, Horodyský P, Růžek D, Novobilský A, Salát J, Strnad M, Sonenshine D, Grubhoffer L, Nebesářová J. Sci Rep.13;10(1): 165. doi: 10.1038/s41598-019-56811-2.

FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells. 2020. Stefanik M, Valdes JJ, Ezebuo FC, Haviernik J, Uzochukwu IC, Fojtikova M, Salat J, Eyer L, Ruzek D. Microorganisms, 20;8(4): E599.doi: 10.3390/microorganisms8040599.

Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples. 2020. Hofmanová J, Slavík J, Ovesná P, Tylichová Z, Dušek L, Straková N, Vaculová AH, Ciganek M, Kala Z, Jíra M, Penka I, Kyclová J, Kolář Z, Kozubík A, Machala M, Vondráček J. PLoS One. 30;15(1): e0228010. doi: 10.1371/journal.pone.0228010.

Gadolinium labelled nanoliposomes as the platform for MRI theranostics:in vitrosafety study in liver cells and macrophages. 2020. Šimečková P, Hubatka F, Kotouček J, Turánek Knötigová P, Mašek J, Slavík J, Kováč O, Neča J, Kulich P, Hrebík D, Stráská J, Pěnčíková K, Procházková J, Diviš P, Macaulay S, Mikulík R, Raška M, Machala M, Turánek J. Sci Rep,16;10(1):4780. doi: 10.1038/s41598-020-60284-z.

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation. 2020. Kotouček J, Hubatka F, Mašek J, Kulich P, Velínská K, Bezděková J, Fojtíková M, Bartheldyová E, Tomečková A, Stráská J, Hrebík D, Macaulay S, Kratochvílová I, Raška M, Turánek J. Sci Rep, 27;10(1):5595. doi: 10.1038/s41598-020-62500-2.

Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes. 2020. Svadlakova T, Hubatka F, Turanek Knotigova P, Kulich P, Masek J, Kotoucek J, Macak J, Motola M, Kalbac M, Kolackova M, Vankova R, Vicherkova P, Malkova A, Simeckova P, Volkov Y, Prina-Mello A, Kratochvilova I, Fiala Z, Raska M, Krejsek J, Turanek J. Nanomaterials(Basel), 27;10(3):E418. doi: 10.3390/nano10030418.


2019

New opportunities for designing effective small interfering RNAs. 2019. Valdés JJ, Miller AD. Sci Rep, 9(1):16146. doi: 10.1038/s41598-019-52303-5.

Diadenosine-Polyphosphate Analogue AppCH2ppA Suppresses Seizures by Enhancing Adenosine Signaling in the Cortex. 2019. Pons-Bennaceur A,Tsintsadze V, Bui T, Tsintsadze T, Minlebaev M, Milh M, Scavarda D, Giniatullin R, Giniatullina R, Shityakov S, Wright M, Miller AD, Lozovaya N, Burnashev N. Cerebral Cortex, 29(9):3778–3795. doi:10.1093/cercor/bhy257.

Tick-borne Encephalitis in Europe and Russia: Review of Pathogenesis, Clinical Features, Therapy, and Vaccines. 2019. Ruzek D, Avšič Županc T, Borde J, Chrdle A, Eyer L, Karganova G, Kholodilov I, Knap N, Kozlovskaya L, Matveev A, Miller AD, Osolodkin DI, Överby AK, Tikunova N, Tkachev S, Zajkowska J. Antiviral Res,164:23-51. doi:10.1016/j.antiviral.2019.01.014.

Phylogenetic Analysis of Lednice Orthobunyavirus. 2019. Berčič RL, Bányai K, Růžek D, Fehér E, Domán M, Danielová V, Bakonyi T, Nowotny N. Microorganisms. 13;7(10): E447. doi: 10.3390/microorganisms7100447.

An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. 2019. Eyer L, Nougairède A, Uhlířová M, Driouich JS, Zouharová D, Valdés JJ, Haviernik J, Gould EA, De Clercq E, de Lamballerie X, Ruzek D. J Virol. 30;93(16): e00367-19. doi: 10.1128/JVI.00367-19.

n-3 Polyunsaturated fatty acids alter benzo[a]pyrene metabolism and genotoxicity in human colon epithelial cell models. 2019. Tylichová Z, Neča J, Topinka J, Milcová A, Hofmanová J, Kozubík A,Machala M, Vondráček J. Food Chem Toxicol, 124:374-384. doi: 10.1016/j.fct.2018.12.021.

Bulky DNA Adducts, microRNA Profiles, and Lipid Biomarkers in Norwegian Tunnel Finishing Workers Occupationally Exposed to Diesel Exhaust. 2019. Rynning I, Arlt VM, Vrbova K, Neča J, Rossner P Jr, Klema J, Ulvestad B, Petersen E, Skare Ø, Haugen A, Phillips DH, Machala M, Topinka J, Mollerup S. Occup Environ Med, 76(1):10-16.
doi: 10.1136/oemed-2018-105445.

Screening of Cellular Stress Responses Induced by Ambient Aerosol Ultrafine Particle Fraction PM0.5 in A549 Cells. 2019. Šimečková P, Marvanová S, Kulich P, Králiková L, Neča J, Procházková J,Machala M. Int J Mol Sci, 13;20(24):6310. doi: 10.3390/ijms20246310.

Colon Cancer and Perturbations of the Sphingolipid Metabolism. 2019. Machala M, Procházková J, Hofmanová J, Králiková L, Slavík J, Tylichová Z, Ovesná P, Kozubík A, Vondráček J. Int J Mol Sci, 30;20(23):6051. doi: 10.3390/ijms20236051.

Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit® Polymers as a Part of Hypromellose K100M Matrix Systems. 2019. Mašková E, Naiserová M, Kubová K, Mašek J, Pavloková S, Urbanová M, Brus J, Vysloužil J, Vetchý D. Biomed Res Int.doi: 10.1155/2019/8043415.

Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization. 2019. Knötigová PT, Mašek J, Hubatka F, Kotouček J, Kulich P, Šimečková P, Bartheldyová E, Machala M, Švadláková T, Krejsek J, Vaškovicová N, Skoupý R, Krzyžánek V, Macaulay S, Katzuba M, Fekete L, Ashcheulov P, Raška M, Kratochvílová I, Turánek J. Mol Pharm, 5;16(8):3441-3451. doi: 10.1021/acs.molpharmaceut.9b00225.

Bioimmunological activities of Candida glabrata cellular mannan. 2019. Paulovičová L, Paulovičová E, Farkaš P, Čížová A, Bystrický P, Jančinová V, Turánek J, Pericolini E, Gabrielli E, Vecchiarelli A, Hrubiško M. FEMS Yeast Res, 1;19(2): foz009. doi: 10.1093/femsyr/foz009.

N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells. 2019. Bartheldyová E, Turánek Knotigová P, Zachová K, Mašek J, Kulich P, Effenberg R, Zyka D, Hubatka F, Kotouček J, Čelechovská H, Héžová R, Tomečková A, Mašková E, Fojtíková M, Macaulay S, Bystrický P, Paulovičová L, Paulovičová E, Drož L, Ledvina M, Raška M, Turánek J. Carbohydr Polym, 1;207:521-532. doi: 10.1016/j.carbpol.2018.10.121.

Proteins mimicking epitope of HIV-1 virus neutralizing antibody induce virus-neutralizing sera in mice. 2019. Kosztyu P, Kuchar M, Cerny J, Barkocziova L, Maly M, Petrokova H, Czernekova L, Liskova V, Raskova Kafkova L, Knotigova P, Masek J, Turanek J, Maly P, Raska M. EBioMedicine, 47:247-256. doi: 10.1016/j.ebiom.2019.07.015.

Targeting Human Thrombus by Liposomes Modified with Anti-Fibrin Protein Binders. 2019. Petroková H, Mašek J, Kuchař M, Vítečková Wünschová A, Štikarová J, Bartheldyová E, Kulich P, Hubatka F, Kotouček J, Knotigová PT, Vohlídalová E, Héžová R, Mašková E, Macaulay S, Dyr JE, Raška M, Mikulík R, Malý P, Turánek J. Pharmaceutics, 2;11(12):642. doi: 10.3390/pharmaceutics11120642.


2018

Characterisation of Zika Virus Infection in Primary Human Astrocytes. 2018. Stefanik M, Formanova P, Bily T, Vancova M, Eyer L, Palus M, Salat J, Torres Braconi C, de A Zanotto PM, Gould EA, Ruzek D. BMC Neurosci, 19(1):5. doi: 10.1186/s12868-018-0407-2.

A Novel Locus on Mouse Chromosome 7 That Influences Survival After Infection With Tick-Borne Encephalitis Virus. 2018. Palus M, Sohrabi Y, Broman KW, Strnad H, Šíma M, žek D, Volkova V, Slapničková M, Vojtíšková J, Mrázková L, Salát J, Lipoldová M. BMC Neurosci,19(1):39. doi: 10.1186/s12868-018-0438-8.

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses. 2018. Haviernik J, Štefánik M, Fojtíková M, Kali S, Tordo N, Rudolf I, Hubálek Z, Eyer L, Ruzek D. Viruses, 10(4):184. doi: 10.3390/v10040184.

Kyasanur Forest Disease Virus Infection Activates Human Vascular Endothelial Cells and Monocyte-Derived Dendritic Cells. 2018. Sirmarova J, Salat J, Palus M, nigV, Langhansova H, Holbrook MR, Ruzek D. Emerg Microbes Infect, 7(1):175. doi: 10.1038/s41426-018-0177-z.

Tick Galactosyltransferases Are Involved in α-Gal Synthesis and Play a Role During Anaplasma Phagocytophilum Infection and Ixodes Scapularis Tick Vector Development. 2018. Cabezas-Cruz A, Espinosa PJ, Alberdi P, Šimo L, Valdés JJ, Mateos-Hernández L, Contreras M, Villar Rayo M, de la Fuente J. Sci Rep, 8(1):14224. doi: 10.1038/s41598-018-32664-z.

Nucleoside Analogs as a Rich Source of Antiviral Agents Active Against Arthropod-Borne Flaviviruses. 2018. Eyer L, Nencka R, de Clercq E, Seley-Radtke K, Růžek D. Antivir Chem Chemother. doi: 10.1177/2040206618761299.

Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use. 2018. Salát J, Formanová P, Huňady M, Eyer L, Palus M, Ruzek D. Vaccine, 36(48):7257-7261. doi: 10.1016/j.vaccine.2018.10.034

Functional evolution of Subolesin/Akirin. 2018. Artigas-Jerónimo S, Villar M, Cabezas-Cruz A,Valdes JJ, Estrada-Peña A,Alberdi P, De La Fuente J. Front. Physiol, 9: 1612. doi: 10.3389/fphys.2018.01612.

Hyaluronic Acid Surface Modified Liposomes Prepared via Orthogonal Aminoxy Coupling: Synthesis of Nontoxic Aminoxylipids Based on Symmetrically α-Branched Fatty Acids, Preparation of Liposomes by Microfluidic Mixing, and Targeting to Cancer Cells Expressing CD44. 2018.Bartheldyová E, Effenberg R, Mašek J,Procházka L,Turánek Knötigová P, Kulich P, Hubatka F, Velínská K, Zelníčková J, Zouharová D, Fojtíková M, Hrebík D, Plevka P, Mikulík R, Miller AD, Macaulay S, Zyka D, Drož L, Raška M, Ledvina M, Turánek J. Bioconjug Chem,29(7):2343-2356. doi: 10.1021/acs.bioconjchem.8b00311.

2017

Escape of tick-borne flavivirus from 2′-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness. 2017. Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. J Virol 91:e01028-17. https://doi.org/10.1128/JVI.01028-17
 
 
Lasioglossins LLIII affect the morphogenesis of Candida albicans and reduces the duration of experimental vaginal candidiasis in mice. 2017. Vrablikova A,Czernekova L,Cahlikova R,Novy Z,Petrik M,Imran S,Novak Z,Krupka M,Cerovsky V,Turanek J,Raska M. Microbiol Immunol, 61(11):474-481. doi: 10.1111/1348-0421.12538.
 
 
Nonpyrogenic Molecular Adjuvants Based on norAbu-Muramyldipeptide and norAbu-Glucosaminyl Muramyldipeptide: Synthesis, Molecular Mechanisms of Action, and Biological Activities in Vitro and in Vivo. 2017. Effenberg R,Turánek Knötigová P,Zyka D,Čelechovská H,Mašek J,Bartheldyová E,Hubatka F,Koudelka Š,Lukáč R,Kovalová A,Šaman D,Křupka M,Barkocziova L,Kosztyu P,Šebela M,Drož L,Hučko M,Kanásová M,Miller AD,Raška M,Ledvina M,Turánek J. J Med Chem 28;60(18):7745-7763. https://doi.org/10.1021/acs.jmedchem.7b00593
 
Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines. 2017. Masek J, Lubasova D, Lukac R, Turanek-Knotigova P, Kulich P, Plockova J, Maskova E, Prochazka L, Koudelka S, Sasithorn N, Gombos J, Bartheldyova E, Hubatka F, Raska M, Miller AD, Turanek J. J Control RElease 249:183-195. https://doi.org/10.1016/j.jconrel.2016.07.036
Publications - first pages only
Effenberg et al 2017

Nonpyrogenic Molecular Adjuvants Based on norAbu-Muramyldipeptide and norAbu-Glucosaminyl Muramyldipeptide:Synthesis, Molecular Mechanisms of Action, and Biological Activities in Vitro and in Vivo

Eyer et al 2017

Escape of Tick-Borne Flavivirus from 2´-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

Masek et al 2016

Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines